Pagets disease of bone – Symptoms and causes / Article
Pagets disease of bone – Symptoms and causes / Article – Paget’s bone disease impedes your body’s normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, the disease can become fragile and mihapen to the affected bones. Paget’s bone disease most commonly occurs in the pelvis, skull, spine and legs.
The risk of Paget’s bone disease increases with age. If a family member has a disorder, your risk also increases. Complications of Paget’s bone disease may include broken bones in your spine, loss of hearing and pinched nerves.
Bisphosphonates – medicines used to strengthen bones weakened by osteoporosis – are the mainstay of treatment. Surgery may be necessary for patients who have complications.
Symptoms – Pagets disease of bone – Symptoms and causes / Article
Most people who have Paget’s bone disease have no symptoms. When symptoms occur, the most common complaint is bone pain.
Because the disease causes your body to produce new bone faster than normal, rapidly produces remodeling bone that is softer and weaker than normal bone, which can cause bone pain, deformities, and fractures. Huh.
The disease can affect only one or two areas of your body or may be widespread. Your signs and symptoms, if any, will depend on the affected part of your body.
Pelvis. Paget’s bone disease in pelvis can cause hip pain.
Skull. An overgrowth of bone in the skull can cause hearing loss or headache.
spinal cord. If your spine is affected, the nerve roots may become compressed. This may cause pain, twitching, and numbness in the hands or feet.
leg. As bones weaken, they may bend – causing you to bend. Enlarged and Mihapen bones in your legs can put additional strain on nearby joints, causing osteoarthritis in your knee or hip.
Causes – Pagets disease of bone – Symptoms and causes / Article
The cause of Paget’s bone disease is unknown. Scientists suspect that a combination of environmental and genetic factors contribute to the disease. Many genes appear to be linked to the disease.
Some scientists believe Paget’s bone disease is related to a viral infection in your bone cells, but this theory is controversial.
If you do not have symptoms, you may not need treatment. However, if the disease is active – indicated by an elevated alkaline phosphate level – and is affecting high-risk sites in your body, such as your scalp or spine, your doctor may recommend treatment to prevent complications. Is, even if you don’t have it. Symptoms.
Medications – Pagets disease of bone – Symptoms and causes / Article
Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget’s bone disease. Some bisphosphonates are taken by mouth, while others are given by injection. Oral bisphosphonates are generally well tolerated, but they can disturb your gastrointestinal tract. examples include:
- Alendronate (Fosamax)
- Ibandronate (Boniva)
- Pamidronate (Aridia)
- Risedronate (Actonel)
- Zoledronic Acid (Zometa, Reclast)
Rarely, bisphosphonate therapy has been associated with severe muscle, joint, or bone pain, which may not resolve when the drug is discontinued. Bisphosphonates may also increase the risk of a rare condition in which a section of the jawbone dies and worsens (osteocrosis of the jawbone), usually associated with active dental disease or oral surgery.
If you cannot tolerate bisphosphonates, your doctor may prescribe calcitonin (miaclassin), a hormone naturally involved in the regulation of calcium and bone metabolism. Calcitonin is a medicine that you administer yourself by injection or nasal spray. Side effects may include nausea, facial flushing, and irritation at the injection site.
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